Impact of the MIF -173G/C variant on cardiovascular disease risk: a meta-analysis of 9,047 participants.

ABSTRACT:

Introduction

Many factors contribute to the risk of cardiovascular disease (CVD), an umbrella term for several different heart diseases, including inflammation. Macrophage migration inhibitory factor (MIF) is an important immune modulator that has been shown to be involved in the pathogenesis of different heart diseases, so understanding pathogenic variants of the MIF gene is important for risk stratification. We therefore conducted a meta-analysis to investigate whether the MIF -173G/C (rs755622) polymorphism is associated with CVD.

Methods

The PubMed, Science Direct, and Embase databases were searched from inception to June 2023 for case-control studies of the MIF -173G/C polymorphism and its relationship to any type of CVD. Correlations between the

SUBMITTER: Fouda H 

PROVIDER: S-EPMC10929265 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature