Oral streptococci <i>S. anginosus</i> and <i>S. mitis</i> induce distinct morphological, inflammatory, and metabolic signatures in macrophages.

ABSTRACT: Oral streptococci, key players in oral biofilm formation, are implicated in oral dysbiosis and various clinical conditions, including dental caries, gingivitis, periodontal disease, and oral cancer. Specifically, Streptococcus anginosus is associated with esophageal, gastric, and pharyngeal cancers, while Streptococcus mitis is linked to oral cancer. However, no study has investigated the mechanistic links between these Streptococcus species and cancer-related inflammatory responses. As an initial step, we probed the innate immune response triggered by S. anginosus and S. mitis in RAW264.7 macrophages. These bacteria exerted time- and dose-dependent effects on macrophage morphology without affecting cell viability. Compared with untreated macrophages, mac

SUBMITTER: Senthil Kumar S 

PROVIDER: S-EPMC10929413 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature