Evaluation of the Observational Associations and Shared Genetics Between Glaucoma With Depression and Anxiety.

ABSTRACT:

Purpose

Glaucoma, a leading cause of blindness worldwide, is suspected to exhibit a notable association with psychological disturbances. This study aimed to investigate epidemiological associations and explore shared genetic architecture between glaucoma and mental traits, including depression and anxiety.

Methods

Multivariable logistic regression and Cox proportional hazards regression models were employed to investigate longitudinal associations based on UK Biobank. A stepwise approach was used to explore the shared genetic architecture. First, linkage disequilibrium score regression inferred global genetic correlations. Second, MiXeR analysis quantified the number of shared causal variants. Third, specific shared loci were detected through conditional/conjunctional false

SUBMITTER: Zhang X 

PROVIDER: S-EPMC10929750 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature