Single-cell transcriptomics identifies senescence-associated secretory phenotype (SASP) features of testicular aging in human.

ABSTRACT: The male reproductive system experiences degradation with age, predominantly impacting the testes. Testicular aging can result in failure to produce physiological testosterone levels, normal sperm concentrations, or both. However, we cannot predict the onset of testicular aging in advance. Using single-cell RNA sequencing (scRNA-seq) from Gene Expression Omnibus (GEO) database, we conducted cell-cell communication network of human testis between older and young group, indicating Leydig cells' potential role in spermatogenesis microenvironment of aging testis. And we depicted the senescence-Associated Secretory Phenotype (SASP) features of aging testis by identifying differentially expressed senescence-associated secretory phenotype (SASP)-related genes between two group. Notably, IGFBP7

SUBMITTER: He J 

PROVIDER: S-EPMC10929807 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature