Relationship between IL-17A gene polymorphism and susceptibility to Kawasaki disease.

ABSTRACT:

Objectives

Kawasaki disease (KD) is the most common autoimmune vasculitis syndrome in children, which supposed be a complex polygenic disorder. Interleukin-17 (IL-17) is a member of the pro-inflammatory cytokine family, which has a strong pro-inflammatory effect and can participate in various acute and chronic inflammatory responses. This study aims to investigate the relationship between the single-nucleotide polymorphism (SNP) locus rs3819025 in the IL-17A gene and the susceptibility to KD.

Methods

A total of 120 patients with KD who met the diagnostic criteria (the KD group) and 120 healthy children (the control group) were enrolled retrospectively in this study. Polymerase chain reaction (PCR) and DNA direct sequencing were used to detect the SNPs of children in t

SUBMITTER: Yang Y 

PROVIDER: S-EPMC10930036 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature