MiR-223-3p increases resistance of colorectal cancer cells to 5-fluorouracil via targeting SORBS1.

ABSTRACT:

Objectives

5-Fluorouracil (5-FU) is the first-line drug for treating colorectal cancer (CRC), and the resistance of tumor cells to 5-FU is the main cause of chemotherapeutic failure. However, the resistant mechanism is still unclear. This study aims to explore the tumor suppressor genes involved in 5-FU resistance in CRC, and to find the microRNA (miRNA) that regulates these genes.

Methods

CRC data sets GSE28702 and GSE69657 were downloaded from Gene Expression Omnibus (GEO) database, and gene expression profiles of patients in the FOLFOX chemotherapeutic response group and the non-response group were analyzed, and differential expression genes were identified between the 2 groups. Target gene was then selected. Online bioinformatics databases TargetScan, miRwalk, and miRDB

SUBMITTER: Lin Y 

PROVIDER: S-EPMC10930083 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature