Identification and verification of key cancer genes associated with prognosis of colorectal cancer based on bioinformatics analysis.

ABSTRACT:

Objectives

The biomarkers targeting colorectal cancer (CRC) prognosis are short of high accuracy and sensitivity in clinic. Through bioinformatics analysis, we aim to identify and confirm a series of key genes referred to the diagnosis and prognosis of CRC.

Methods

GSE31905, GSE35279, and GSE41657 were selected as complete RNA sequencing data sets of CRC and colorectal mucosa (CRM) tissues from the NCBI-GEO database, and the differentially expressed genes (DEGs) were analyzed. The common DEGs in these 3 data sets were obtained by Venn map, and enriched by STRING network system and Cytoscape software. The Kaplan-Meier plotter website was used to verify the correlation between the enriched genes and the prognosis of CRC.

Results

For the whole RNA sequencing data sets of

SUBMITTER: Qin Y 

PROVIDER: S-EPMC10930233 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature