Dataset Information
Expression of PGRMC1 in patients with polycystic ovary syndrome and its molecular mechanism for regulating ovarian granulosa cell apoptosis and glucolipid metabolism.
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ABSTRACT:
SUBMITTER: Zhou J
PROVIDER: S-EPMC10930243 | biostudies-literature | 2023 Apr
REPOSITORIES: biostudies-literature
Publications
Expression of PGRMC1 in patients with polycystic ovary syndrome and its molecular mechanism for regulating ovarian granulosa cell apoptosis and glucolipid metabolism.
Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences 20230401 4
<h4>Objectives</h4>Polycystic ovary syndrome (PCOS) is one of the most common endocrine diseases in women with reproductive age, which is associated with hyperandrogenism, insulin resistance, and ovulatory dysfunction. Progesterone receptor membrane component 1 (PGRMC1) can mediate progesterone to inhibit the apoptosis of ovarian granulosa cells and the growth of follicles, and to induce glucolipid metabolism disorder in ovarian granulosa cells, which is closely related to the occurrence and dev ...[more]
