Relationship between RELN signaling pathway genes and language development of autism based on a cluster model.

ABSTRACT:

Objectives

Autism is a neurodevelopment disorder with unclear etiology. High heterogeneity is one of the main issues in the etiological studies. This study explores the relationship between RELN signaling pathway related genes (RELN, VLDLR, LRP8, DAB1, CDK5, FYN) and language development of autism patients based on a cluster analysis model which is established to reduce the heterogeneity.

Methods

Autism children were recruited from 5 different medical/autism training institutes from Hunan, Shandong, and Henan provinces, and were divided into 2 parts according to the recruitment time: The first part was the training sample, which was recruited from October 2006 to May 2011, and the second part was the validation sample, which was recr

SUBMITTER: Shen Y 

PROVIDER: S-EPMC10930297 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature