Analysis on tumor immune microenvironment and construction of a prognosis model for immune-related skin cutaneous melanoma.

ABSTRACT:

Objectives

Malignant melanoma is a highly malignant and heterogeneous skin cancer. Although immunotherapy has improved survival rates, the inhibitory effect of tumor microenvironment has weakened its efficacy. To improve survival and treatment strategies, we need to develop immune-related prognostic models. Based on the analysis of the Cancer Genome Atlas (TCGA), Gene Expression Omnibus (GEO), and Sequence Read Archive (SRA) database, this study aims to establish an immune-related prognosis prediction model, and to evaluate the tumor immune microenvironment by risk score to guide immunotherapy.

Methods

Skin cutaneous melanoma (SKCM) transcriptome sequencing data and corresponding clinical information were obtained from the TCGA database, differentially expressed genes were a

SUBMITTER: Wu M 

PROVIDER: S-EPMC10930407 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature