Electroporation in Translational Medicine: From Veterinary Experience to Human Oncology.

ABSTRACT: Electroporation (EP) is a broadly accepted procedure that, through the application of electric pulses with appropriate amplitudes and waveforms, promotes the delivery of anticancer molecules in various oncology therapies. EP considerably boosts the absorptivity of targeted cells to anticancer molecules of different natures, thus upgrading their effectiveness. Its use in veterinary oncology has been widely explored, and some applications, such as electrochemotherapy (ECT), are currently approved as first-line treatments for several neoplastic conditions. Other applications include irreversible electroporation and EP-based cancer vaccines. In human oncology, EP is still mostly restricted to therapies for cutaneous tumors and the palliation of cutaneous and visceral metastases of malignant tu

SUBMITTER: Spugnini EP 

PROVIDER: S-EPMC10930471 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature