Targeted DNA Methylation Editing Using an All-in-One System Establishes Paradoxical Activation of EBF3.

ABSTRACT: Cutaneous melanoma is rapidly on the rise globally, surpassing the growth rate of other cancers, with metastasis being the primary cause of death in melanoma patients. Consequently, understanding the mechanisms behind this metastatic process and exploring innovative treatments is of paramount importance. Recent research has shown promise in unravelling the role of epigenetic factors in melanoma progression to metastasis. While DNA hypermethylation at gene promoters typically suppresses gene expression, we have contributed to establishing the newly understood mechanism of paradoxical activation of genes via DNA methylation, where high methylation coincides with increased gene activity. This mechanism challenges the conventional paradigm that promoter methylation solely silences genes, sugge

SUBMITTER: Banerjee R 

PROVIDER: S-EPMC10930647 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature