Gene Signature of Regulatory T Cells Isolated from Children with Selective IgA Deficiency and Common Variable Immunodeficiency.

ABSTRACT: Selective IgA deficiency (SIgAD) is the most common form and common variable immunodeficiency (CVID) is the most symptomatic form of predominant antibody deficiency. Despite differences in the clinical picture, a similar genetic background is suggested. A common feature of both disorders is the occurrence of autoimmune conditions. Regulatory T cells (T_regs) are the major immune cell type that maintains autoimmune tolerance. As the different types of abnormalities of T_reg cells have been associated with autoimmune disorders in primary immunodeficiency (PID) patients, in our study we aimed to analyze the gene expression profiles of T_reg cells in CVID and SIgAD patients compared to age-matched healthy controls. The transcriptome-wide gene profiling was perform

SUBMITTER: Rutkowska-Zapala M 

PROVIDER: S-EPMC10930802 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature