Lamin A/C and PI(4,5)P2-A Novel Complex in the Cell Nucleus.

ABSTRACT: Lamins, the nuclear intermediate filaments, are important regulators of nuclear structural integrity as well as nuclear functional processes such as DNA transcription, replication and repair, and epigenetic regulations. A portion of phosphorylated lamin A/C localizes to the nuclear interior in interphase, forming a lamin A/C pool with specific properties and distinct functions. Nucleoplasmic lamin A/C molecular functions are mainly dependent on its binding partners; therefore, revealing new interactions could give us new clues on the lamin A/C mechanism of action. In the present study, we show that lamin A/C interacts with nuclear phosphoinositides (PIPs), and with nuclear myosin I (NM1). Both NM1 and nuclear PIPs have been previously reported as important regulators of gene expression and

SUBMITTER: Escudeiro-Lopes S 

PROVIDER: S-EPMC10931150 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature