Dataset Information

Concurrent Validation of MI-CAT(V), a Clinical Metrology Instrument for Veterinarians Assessing Osteoarthritis Pain in Cats, through Testing for Firocoxib Analgesic Efficacy in a Prospective, Randomized, Controlled, and Blinded Study.

ABSTRACT: Veterinarians face the lack of a rapid, reliable, inexpensive, and treatment-sensitive metrological instrument reflecting feline osteoarthritis (OA) pain. The Montreal Instrument for Cat Arthritis Testing, for Use by Veterinarians (MI-CAT(V)) has been refined in 4 sub-sections, and we proposed its concurrent validation. Cats naturally affected by OA (n = 32) were randomly distributed into 4 groups of firocoxib analgesic (Gr. A: 0.40; B: 0.25; C: 0.15, and P: 0.00 mg/kg bodyweight). They were assessed during Baseline, Treatment, and Recovery periods using MI-CAT(V) and objective outcomes (effort path, stairs assay compliance, and actimetry). The MI-CAT(V) total score correlated to the effort path and actimetry (Rho_S = -0.501 to -0.453; p < 0.001), also being sensitive to treatment responsiveness. The pooled treatment group improved its total, gait, and body posture scores during Treatment compared to the Baseline, Recovery, and placebo group (p < 0.05). The MI-CAT(V) suggested a dose-(especially for Gr. B) and cluster-response. Cats in the moderate and severe MI-CAT(V) clusters responded to firocoxib with a remaining analgesic effect, while the mild cluster seemed less responsive and experienced a negative rebound effect. The MI-CAT(V) was validated for its OA pain severity discriminatory abilities and sensitivity to firocoxib treatment, providing a new perspective for individualized care.

SUBMITTER: Delsart A

PROVIDER: S-EPMC10931368 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Concurrent Validation of MI-CAT(V), a Clinical Metrology Instrument for Veterinarians Assessing Osteoarthritis Pain in Cats, through Testing for Firocoxib Analgesic Efficacy in a Prospective, Randomized, Controlled, and Blinded Study.

Delsart Aliénor A Otis Colombe C Leung Vivian S Y VSY Labelle Émilie É Moreau Maxim M Frezier Marilyn M Drag Marlene M Martel-Pelletier Johanne J Pelletier Jean-Pierre JP Troncy Eric E

Animals : an open access journal from MDPI 20240224 5

Veterinarians face the lack of a rapid, reliable, inexpensive, and treatment-sensitive metrological instrument reflecting feline osteoarthritis (OA) pain. The Montreal Instrument for Cat Arthritis Testing, for Use by Veterinarians (MI-CAT(V)) has been refined in 4 sub-sections, and we proposed its concurrent validation. Cats naturally affected by OA (<i>n</i> = 32) were randomly distributed into 4 groups of firocoxib analgesic (Gr. A: 0.40; B: 0.25; C: 0.15, and P: 0.00 mg/kg bodyweight). They w ...[more]

PMID: 38473097

Similar Datasets

Project description:ObjectivesThe aim of this study was two-fold: first, to investigate the attitudes and application of cat-friendly practices among German, French and Swiss veterinarians during consultations; and second, to gain a better understanding of the relationship between the demographics of the veterinarians and variations in the application of cat-friendly practices and attitudes.MethodsA bilingual questionnaire structured around the capability, opportunity, motivation and behaviour (COM-B) model of human behaviour was distributed to veterinarians in Germany, France and Switzerland. Using Likert scales, participants were asked to report on their application of cat-friendly practices during consultations and their attitudes towards cat-friendly methods. The proportion of cat-friendly practices and attitudes were identified by grouping results across Likert scales. Multiple binary logistic regression models were performed to compare the differences in cat-friendly practices and attitudes across the three countries. Cumulative scores were calculated for practices and attitudes, and analysed for associations with veterinarian demographics using a general linear model.ResultsOf the 516 respondents, 36.2% used scruffing to restrain cats, 51.9% prescribed anxiolytics for future visits and 17.1% used medication to mitigate stress during consultations. Only 37.6% thought that caregivers expected to be educated on how to prevent or reduce stress in their cats during transport. Having an employee position rather than being clinic director or partner was associated with a lower score of cat-friendly practices (P <0.01) and motivation (P = 0.02). Whereas, awareness of cat-friendly guidelines, working in a Cat Friendly or Fear Free accredited clinic and being trained in animal behaviour contributed to higher scores in both cat-friendly practices and overall attitudes (P <0.001).Conclusions and relevanceEducation and promotion of guidelines on cat-friendly practices will facilitate improvements in handling cats and mitigating fear-anxiety with medication.

Project description:BackgroundSmall intestinal strangulating obstruction (SISO) is associated with endotoxaemia which leads to an increased risk of death. Nonsteroidal anti-inflammatory drugs (NSAIDs) are used to treat signs of endotoxaemia by inhibiting cyclo-oxygenases (COX). COX-1 is expressed constitutively and promotes gut barrier function, whereas COX-2 is inducible and contributes to the signs of endotoxaemia. In preclinical SISO trials, intestinal barrier recovery was more complete with reductions in endotoxin permeability in horses treated with COX-2 selective NSAIDs as compared with horses treated with flunixin meglumine.ObjectivesWe hypothesised that treatment of post-surgical SISO horses with firocoxib (COX-2 selective) would reduce the signs of endotoxaemia to a greater extent than flunixin meglumine (nonselective COX inhibitor) while continuing to provide similar levels of pain control.Study designBlinded randomised clinical trial.MethodsIn addition to clinical monitoring, preoperative and 12-, 24- and 48-h post-operative plasma samples were assessed for prostaglandin E2 (PGE2 ), thromboxane B2 (TXB2 ), TNF⍺ and soluble CD14 (sCD14).ResultsIn 56 recruited SISO horses, either flunixin meglumine (1.1 mg/kg, i.v., q12h) or firocoxib (0.3 mg/kg, i.v. loading dose; 0.1 mg/kg, i.v., q24h) was given in the post-operative period in three university hospitals from 2015 to 2017. COX-2 selectivity was confirmed by a relative lack of inhibition of the COX-1 prostanoid TXB2 by firocoxib and significant inhibition by flunixin meglumine (P = 0.014). Both drugs inhibited the COX-2 prostanoid PGE2 . There were no significant differences in pain scores between groups (P = 0.2). However, there was a 3.23-fold increased risk (P = 0.04) of increased plasma sCD14 in horses treated with flunixin meglumine, a validated biomarker of equine endotoxaemia.Main limitationsHorses were all treated with flunixin meglumine prior to referral. In addition, many horses were treated with lidocaine, which has been shown to mitigate the deleterious effects of flunixin meglumine.ConclusionsIn SISO cases, firocoxib reduced a biomarker of endotoxaemia as compared with flunixin meglumine while continuing to provide similar levels of pain control.

Dataset Information

Concurrent Validation of MI-CAT(V), a Clinical Metrology Instrument for Veterinarians Assessing Osteoarthritis Pain in Cats, through Testing for Firocoxib Analgesic Efficacy in a Prospective, Randomized, Controlled, and Blinded Study.

Publications

Concurrent Validation of MI-CAT(V), a Clinical Metrology Instrument for Veterinarians Assessing Osteoarthritis Pain in Cats, through Testing for Firocoxib Analgesic Efficacy in a Prospective, Randomized, Controlled, and Blinded Study.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets