Harnessing the Diversity of Burkholderia spp. Prophages for Therapeutic Potential.

ABSTRACT: Burkholderia spp. are often resistant to antibiotics, and infections with these organisms are difficult to treat. A potential alternative treatment for Burkholderia spp. infections is bacteriophage (phage) therapy; however, it can be difficult to locate phages that target these bacteria. Prophages incorporated into the bacterial genome have been identified within Burkholderia spp. and may represent a source of useful phages for therapy. Here, we investigate whether prophages within Burkholderia spp. clinical isolates can kill conspecific and heterospecific isolates. Thirty-two Burkholderia spp. isolates were induced for prophage release, and harvested phages were tested for lytic activity against the same 32 isolates. Temperate phages were passaged and th

SUBMITTER: Nordstrom HR 

PROVIDER: S-EPMC10931425 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature