Potential selection of antimony and methotrexate cross-resistance in Leishmania infantum circulating strains.

ABSTRACT:

Background

Visceral leishmaniasis (VL) resolution depends on a wide range of factors, including the instauration of an effective treatment coupled to a functional host immune system. Patients with a depressed immune system, like the ones receiving methotrexate (MTX), are at higher risk of developing VL and refusing antileishmanial drugs. Moreover, the alarmingly growing levels of antimicrobial resistance, especially in endemic areas, contribute to the increasing the burden of this complex zoonotic disease.

Principal findings

To understand the potential links between immunosuppressants and antileishmanial drugs, we have studied the interaction of antimony (Sb) and MTX in a Leishmania infantum reference strain (LiWT) and in two L. infantum clinical strains (LiFS-A and LiFS-B)

SUBMITTER: Bernardo L 

PROVIDER: S-EPMC10931519 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature