Epigenetic Mechanisms in Latent Epstein-Barr Virus Infection and Associated Cancers.

ABSTRACT: The Epstein-Barr Virus (EBV) is a double-stranded DNA-based human tumor virus that was first isolated in 1964 from lymphoma biopsies. Since its initial discovery, EBV has been identified as a major contributor to numerous cancers and chronic autoimmune disorders. The virus is particularly efficient at infecting B-cells but can also infect epithelial cells, utilizing an array of epigenetic strategies to establish long-term latent infection. The association with histone modifications, alteration of DNA methylation patterns in host and viral genomes, and microRNA targeting of host cell factors are core epigenetic strategies that drive interactions between host and virus, which are necessary for viral persistence and progression of EBV-associated diseases. Therefore, understanding epigenetic r

SUBMITTER: Torne AS 

PROVIDER: S-EPMC10931536 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature