Enhanced Diaphragm Muscle Function upon Satellite Cell Transplantation in Dystrophic Mice.

ABSTRACT: The diaphragm muscle is essential for breathing, and its dysfunctions can be fatal. Many disorders affect the diaphragm, including muscular dystrophies. Despite the clinical relevance of targeting the diaphragm, there have been few studies evaluating diaphragm function following a given experimental treatment, with most of these involving anti-inflammatory drugs or gene therapy. Cell-based therapeutic approaches have shown success promoting muscle regeneration in several mouse models of muscular dystrophy, but these have focused mainly on limb muscles. Here we show that transplantation of as few as 5000 satellite cells directly into the diaphragm results in consistent and robust myofiber engraftment in dystrophin- and fukutin-related protein-mutant dystrophic mice. Transplanted cells also

SUBMITTER: Azzag K 

PROVIDER: S-EPMC10931593 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature