The Transcriptional Landscape of Immune-Response 3'-UTR Alternative Polyadenylation in Melanoma.

ABSTRACT: The prognosis of patients with malignant melanoma has been improved in recent decades due to advancements in immunotherapy. However, a considerable proportion of patients are refractory to treatment, particularly at advanced stages. This underscores the necessity of developing a new strategy to improve it. Alternative polyadenylation (APA), as a marker of crucial posttranscriptional regulation, has emerged as a major new type of epigenetic marker involved in tumorigenesis. However, the potential roles of APA in shaping the tumor microenvironment (TME) are largely unexplored. Herein, we collected two cohorts comprising melanoma patients who received immune checkpoint inhibitor (ICI) immunotherapy to quantify transcriptome-wide discrepancies in APA. We observed a global change in 3'-UTRs bet

SUBMITTER: Yang X 

PROVIDER: S-EPMC10931711 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature