Role of Advanced Glycation End Products as New Biomarkers in Systemic Lupus Erythematosus.

ABSTRACT: Advanced glycation end-products (AGEs) may play a relevant role as inducers in the chronic inflammatory pathway present in immune-mediated diseases, such as systemic lupus erythematosus (SLE). AGEs concentrations have been associated, with discrepant results to date, with some parameters such as disease activity or accrual damage, suggesting their potential usefulness as biomarkers of the disease. Our objectives are to confirm differences in AGEs levels measured by cutaneous autofluorescence between SLE patients and healthy controls (HC) and to study their correlation with various disease parameters. Cross-sectional study, where AGEs levels were measured by skin autofluorescence, and SLE patients' data were compared with those of sex- and age-matched HC in a 1:3 proportion through a multip

SUBMITTER: Carrion-Barbera I 

PROVIDER: S-EPMC10931748 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature