Myeloid-Derived Suppressor Cells: Therapeutic Target for Gastrointestinal Cancers.

ABSTRACT: Gastrointestinal cancers represent one of the more challenging cancers to treat. Current strategies to cure and control gastrointestinal (GI) cancers like surgery, radiation, chemotherapy, and immunotherapy have met with limited success, and research has turned towards further characterizing the tumor microenvironment to develop novel therapeutics. Myeloid-derived suppressor cells (MDSCs) have emerged as crucial drivers of pathogenesis and progression within the tumor microenvironment in GI malignancies. Many MDSCs clinical targets have been defined in preclinical models, that potentially play an integral role in blocking recruitment and expansion, promoting MDSC differentiation into mature myeloid cells, depleting existing MDSCs, altering MDSC metabolic pathways, and directly inhibiting M

SUBMITTER: Arshad J 

PROVIDER: S-EPMC10931832 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature