Similarities in Structure and Function of UDP-Glycosyltransferase Homologs from Human and Plants.

ABSTRACT: The uridine diphosphate glycosyltransferase (UGT) superfamily plays a key role in the metabolism of xenobiotics and metabolic wastes, which is essential for detoxifying those species. Over the last several decades, a huge effort has been put into studying human and mammalian UGT homologs, but family members in other organisms have been explored much less. Potentially, other UGT homologs can have desirable substrate specificity and biological activities that can be harnessed for detoxification in various medical settings. In this review article, we take a plant UGT homology, UGT71G1, and compare its structural and biochemical properties with the human homologs. These comparisons suggest that even though mammalian and plant UGTs are functional in different environments, they may support simi

SUBMITTER: Lethe MCL 

PROVIDER: S-EPMC10932239 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature