Neutrophils at the Crossroads: Unraveling the Multifaceted Role in the Tumor Microenvironment.

ABSTRACT: Over the past decade, research has prominently established neutrophils as key contributors to the intricate landscape of tumor immune biology. As polymorphonuclear granulocytes within the innate immune system, neutrophils play a pivotal and abundant role, constituting approximately ∼70% of all peripheral leukocytes in humans and ∼10-20% in mice. This substantial presence positions them as the frontline defense against potential threats. Equipped with a diverse array of mechanisms, including reactive oxygen species (ROS) generation, degranulation, phagocytosis, and the formation of neutrophil extracellular traps (NETs), neutrophils undeniably serve as indispensable components of the innate immune system. While these innate functions enable neutrophils to interact with adaptive immune cells

SUBMITTER: Awasthi D 

PROVIDER: S-EPMC10932322 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature