IBio-GATS-A Semi-Automated Workflow for Structural Modelling of Insect Odorant Receptors.

ABSTRACT: Insects utilize seven transmembrane (7TM) odorant receptor (iOR) proteins, with an inverted topology compared to G-protein coupled receptors (GPCRs), to detect chemical cues in the environment. For pest biocontrol, chemical attractants are used to trap insect pests. However, with the influx of invasive insect pests, novel odorants are urgently needed, specifically designed to match 3D iOR structures. Experimental structural determination of these membrane receptors remains challenging and only four experimental iOR structures from two evolutionarily distant organisms have been solved. Template-based modelling (TBM) is a complementary approach, to generate model structures, selecting templates based on sequence identity. As the iOR family is highly divergent, a different template selection

SUBMITTER: Chidambara Thanu V 

PROVIDER: S-EPMC10932339 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature