Bone-Differentiation-Associated Circ-Spen Regulates Death of Mouse Bone Marrow Mesenchymal Stem Cells by Inhibiting Apoptosis and Promoting Autophagy.

ABSTRACT: The role of estrogen receptor β (ERβ) in bone health is closely associated with its function in vivo, and ERβ^-/- mice have been widely utilized to explore the related influences. In this study, ERβ^-/- female mice were established to investigate the differential expression of circular RNAs (circRNAs) by RNA-Sequencing (RNA-Seq). Among these circRNAs, mmu_circ_0011379 (named Circ-Spen) exhibited high expression in ERβ^-/- female mice. However, the precise mechanism by which Circ-Spen regulates bone health remained unclear. This study identified Circ-Spen as a positive regulator of mouse bone marrow mesenchymal stem cell (mBMSC) viability. The expression of Circ-Spen was markedly increased in ERβ^-/- mice femurs test

SUBMITTER: Liang Z 

PROVIDER: S-EPMC10932347 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature