Dietary intake and serum levels of copper and zinc and risk of hepatocellular carcinoma: A matched case-control study.

ABSTRACT:

Background

Copper and zinc are involved in the development of multiple malignancies; yet, epidemiological evidence on hepatocellular carcinoma (HCC) is limited. This study aimed to investigate the association between dietary intake and serum levels of copper and zinc with the risk of HCC.

Methods

A total of 434 case-control pairs matched for sex and age (±1 year) were included in this study. Cases with newly diagnosed HCC were from the Guangdong Liver Cancer Cohort (GLCC) study, and healthy controls were from the Guangzhou Nutrition and Health Study (GNHS). A semi-quantitative 79-item food frequency questionnaire (FFQ) was used to assess habitual dietary intakes of copper and zinc. Serum levels of copper and zinc were measured by using inductively coupled plasma mass spectro

SUBMITTER: Liu X 

PROVIDER: S-EPMC10932515 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature