Validation of the revised electronic version of RUCAM for diagnosis of DILI in Chinese patients.

ABSTRACT:

Background aims

The Revised Electronic Causality Assessment Method (RECAM), a computerized update of the Roussel Uclaf Causality Assessment Methodology (RUCAM), was recently proposed. In this study, we validated and compared the utility of the RECAM and RUCAM in Chinese patients with a single conventional or herbal agent-induced liver injury.

Methods

In this retrospective multicenter cohort of well-established DILI and non-DILI patients from 5 centers in China, the diagnostic performance of the RUCAM and RECAM was compared by AUC analysis. The consistency was evaluated by weighted kappa. The major causes of discrepancy were explored.

Results

A total of 481 DILI and 100 non-DILI patients were included. In total, 62.6% of the DILI cases were induced by conventional agen

SUBMITTER: Zhao X 

PROVIDER: S-EPMC10932528 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature