Addressing the need for preclinical study of penile prosthesis infection: a new animal model and narrative review.

ABSTRACT:

Background and objective

Erectile dysfunction (ED) is a common condition in men, and many patients refractory to conservative treatment may undergo penile prostheses (PPs) placement. The primary concern following PP implantation is device infection. Although antibiotic and hydrophilic coatings have reduced the incidence of inflatable PP (IPP) infections, there remains room for improvement. Optimization of PP outcomes requires a practical in vivo model to better understand mechanisms of infection and to test new infection control strategies. We aimed to describe a new rabbit model which contains a functional IPP and review previously reported animal PP models.

Methods

An IPP was placed into rabbit flanks and cycled for functionality testing. Rabbits were evaluated for

SUBMITTER: Shah YB 

PROVIDER: S-EPMC10932634 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature