Development and validation of a chromatin regulator signature for predicting prognosis hepatocellular carcinoma patient.

ABSTRACT:

Background

Hepatocellular carcinoma (HCC) is a malignancy with a bleak prognosis. Although emerging research increasingly supports the involvement of chromatin regulators (CRs) in cancer development, CRs in HCC patients have not received proportionate attention. This study aimed to investigate the role and prognostic significance of CRs in HCC patients, providing new insights for clinical diagnosis and treatment strategies.

Methods

We analyzed 424 samples in The Cancer Genome Atlas-Liver hepatocellular carcinoma (TCGA-LIHC) data to identify key CR genes associated with HCC prognosis by differential expression and univariate Cox regression analyses. LASSO-multivariate Cox regression method was used for construction of a prognostic signature and development of a CR-related pro

SUBMITTER: Mao J 

PROVIDER: S-EPMC10932653 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature