Prognostic nomogram in patients with gastrointestinal stromal tumors: a SEER-based study.

ABSTRACT:

Background

Gastrointestinal stromal tumor (GIST) is a common mesenchymal tumor of the gastrointestinal system. They originate from the interstitial cells of Cajal located within the muscle layer and are characterized by over-expression of the tyrosine kinase receptor KIT.

Methods

Data from the Surveillance Epidemiology, and End Results (SEER) database of 1,213 patients diagnosed with GIST between 2010 and 2019 were dichotomized into a modeling set and a validation set at a 2:1 ratio. For the modeling set, both univariate and multivariate Cox regression analyses were used to identify independent prognostic factors. A nomogram was then constructed based on these determinants. Model efficacy was tested using receiver operating characteristic (ROC) curves, calibration curves, cl

SUBMITTER: Xu P 

PROVIDER: S-EPMC10932676 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature