Upregulated expression of PTTG1 is associated with progression of pancreatic cancer.

ABSTRACT:

Background

Pancreatic cancer (PC) is an aggressive disease with a very poor prognosis. The insidious onset, rapid progression, and resistance to conventional therapies mark the imperious need for novel biomarkers and therapeutic targets. The pituitary tumor transforming gene 1 (PTTG1), implicated in tumorigenesis and cellular transformation, has been studied in various cancers, however, its role and mechanisms in PC remain to be elucidated for better understanding the disease pathology and in enhancing patient management strategies.

Methods

The present study examined the PTTG1 messenger RNA (mRNA) expression levels and clinical significance through meta-analysis based on The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases. Immunohistochem

SUBMITTER: He Y 

PROVIDER: S-EPMC10932678 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature