Dominance reversals: the resolution of genetic conflict and maintenance of genetic variation.

ABSTRACT: Beneficial reversals of dominance reduce the costs of genetic trade-offs and can enable selection to maintain genetic variation for fitness. Beneficial dominance reversals are characterized by the beneficial allele for a given context (e.g. habitat, developmental stage, trait or sex) being dominant in that context but recessive where deleterious. This context dependence at least partially mitigates the fitness consequence of heterozygotes carrying one non-beneficial allele for their context and can result in balancing selection that maintains alternative alleles. Dominance reversals are theoretically plausible and are supported by mounting empirical evidence. Here, we highlight the importance of beneficial dominance reversals as a mechanism for the mitigation of genetic conflict and review

SUBMITTER: Grieshop K 

PROVIDER: S-EPMC10932723 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature