Longitudinal reduction in brain volume in patients with schizophrenia and its association with cognitive function.

ABSTRACT: Establishing a brain biomarker for schizophrenia is strongly desirable not only to support diagnosis by psychiatrists but also to help track the progressive changes in the brain over the course of the illness. A brain morphological signature of schizophrenia was reported in a recent study and is defined by clusters of brain regions with reduced volume in schizophrenia patients compared to healthy individuals. This signature was proven to be effective at differentiating patients with schizophrenia from healthy individuals, suggesting that it is a good candidate brain biomarker of schizophrenia. However, the longitudinal characteristics of this signature have remained unclear. In this study, we examined whether these changes occurred over time and whether they were associated with clinical o

SUBMITTER: Yamazaki R 

PROVIDER: S-EPMC10932790 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature