Peripheral and central biomarkers associated with inflammation in antipsychotic naive first episode psychosis: Pilot studies.

ABSTRACT:

Background

Elevated serum pro-inflammatory molecules have been reported in early psychosis. What is not known is whether peripheral inflammatory biomarkers are associated with CNS biomarkers. In the brain, release of pro-inflammatory molecules by microglial hyperactivity may lead to neuronal apoptosis seen in neurodegenerative disorders and account for loss of brain tissue observed in psychotic disorders. Neurochemical changes, including elevated glutamate levels, are also associated with neuroinflammation, present in early psychosis and change with antipsychotic treatment.

Methods

Antipsychotic naïve patients with first episode psychosis (FEP) were studied as part of a collaborative project of neuroinflammation. In Study 1 we explored associations between plasma inflammator

SUBMITTER: Cadenhead KS 

PROVIDER: S-EPMC10932822 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature