Risk subgroups and intervention effects among infants at high risk for peanut allergy: A model for clinical decision making.

ABSTRACT:

Background

The Learning Early About Peanut Allergy (LEAP) trial showed that early dietary introduction of peanut reduced the risk of developing peanut allergy by age 60 months in infants at high risk for peanut allergy. In this secondary analysis of LEAP data, we aimed to determine risk subgroups within these infants and estimate their respective intervention effects of early peanut introduction.

Methods

LEAP raw data were retrieved from ITNTrialShare.org. Conditional random forest was applied to participants in the peanut avoidance arm to select statistically important features for the classification and regression tree (CART) analysis to group infants based on their risk of peanut allergy at 60 months of age. Intervention effects were estimated for each derived risk subgro

SUBMITTER: Li Y 

PROVIDER: S-EPMC10932885 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature