Cognitive, Functional, and Quality of Life Outcomes 6 Months After Mechanical Ventilation for Bronchiolitis: A Secondary Analysis of Data From the Randomized Evaluation of Sedation Titration for Respiratory Failure Trial ( RESTORE ).

ABSTRACT:

Objectives

To describe rates and associated risk factors for functional decline 6 months after critical bronchiolitis in a large, multicenter dataset.

Design

Nonprespecified secondary analysis of existing 6-month follow-up data of patients in the Randomized Evaluation of Sedation Titration for Respiratory Failure trial ( RESTORE , NCT00814099).

Setting

Patients recruited to RESTORE in any of 31 PICUs in the United States, 2009-2013.

Patients

Mechanically ventilated PICU patients under 2 years at admission with a primary diagnosis of bronchiolitis.

Interventions

There were no interventions in this secondary analysis; in the RESTORE trial, PICUs were randomized to protocolized sedation versus usual care.

Measurements and main results

"Functional dec

SUBMITTER: Fischer M 

PROVIDER: S-EPMC10932893 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature