Association between doxycycline use and long-term functioning in patients with schizophrenia.

ABSTRACT:

Importance and objective

The brain-penetrant tetracycline antibiotics, minocycline and doxycycline, have been proposed as potential candidate drugs for treatment of schizophrenia, based on preclinical studies and clinical trials. A potential long-term beneficial effect of these antibiotics for schizophrenia patients has not been investigated. This study was designed to determine if redemption of doxycycline prescription in schizophrenia is associated with decreased incidence of disability pension, a proxy for long-term functioning.

Design

We performed a population-based cohort study with data from schizophrenia patients available through the Danish registers. Survival analysis models with time-varying covariates were constructed to assess incidence rate ratios (IRR) of disab

SUBMITTER: de Witte LD 

PROVIDER: S-EPMC10932900 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature