Metal Activation Produces Different Reaction Environments for Intermediates during Oxidative Addition.

ABSTRACT: Commercial zinc metal powder requires activation for consistent and reliable use as a reductant in the formation of organozinc reagents from organohalides, and for the avoidance of supplier and batch-to-batch variability. However, the impact of activation methods on the reaction environments of subsequent intermediates has been unknown. Herein, a fluorescence lifetime imaging microscopy (FLIM) method is developed to bridge this knowledge gap, by imaging and examining reaction intermediates on zinc metal that has been activated by pretreatment through different common methods (i. e., by chemical activation with TMSCl, dibromoethane, or HCl; or by mechanical activation). The group of chemical activating agents, previously thought to act similarly by removing oxide layers, are here shown to p

SUBMITTER: Hanada EM 

PROVIDER: S-EPMC10932920 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature