Tapping into the human spinal locomotor centres with transspinal stimulation.

ABSTRACT: Human locomotion is controlled by spinal neuronal networks of similar properties, function, and organization to those described in animals. Transspinal stimulation affects the spinal locomotor networks and is used to improve standing and walking ability in paralyzed people. However, the function of locomotor centers during transspinal stimulation at different frequencies and intensities is not known. Here, we document the 3D joint kinematics and spatiotemporal gait characteristics during transspinal stimulation at 15, 30, and 50 Hz at sub-threshold and supra-threshold stimulation intensities. We document the temporal structure of gait patterns, dynamic stability of joint movements over stride-to-stride fluctuations, and limb coordination during walking at a self-selected speed in healthy s

SUBMITTER: Skiadopoulos A 

PROVIDER: S-EPMC10933285 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature