Differential anti-viral response to respiratory syncytial virus A in preterm and term infants.

ABSTRACT:

Background

Preterm infants are more likely to experience severe respiratory syncytial virus (RSV) disease compared to term infants. The reasons for this are multi-factorial, however their immature immune system is believed to be a major contributing factor.

Methods

We collected cord blood from 25 preterm (gestational age 30.4-34.1 weeks) and 25 term infants (gestation age 37-40 weeks) and compared the response of cord blood mononuclear cells (CBMCs) to RSVA and RSVB stimulation using neutralising assays, high-dimensional flow cytometry, multiplex cytokine assays and RNA-sequencing.

Findings

We found that preterm and term infants had similar maternally derived neutralising antibody titres to RSVA and RSVB. Preterm infants had significantly higher myeloid dendritic cell

SUBMITTER: Anderson J 

PROVIDER: S-EPMC10933467 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature