Metabolic reprogramming and signalling cross-talks in tumour-immune interaction: a system-level exploration.

ABSTRACT: Tumour-immune microenvironment (TIME) is pivotal in tumour progression and immunoediting. Within TIME, immune cells undergo metabolic adjustments impacting nutrient supply and the anti-tumour immune response. Metabolic reprogramming emerges as a promising approach to revert the immune response towards a pro-inflammatory state and conquer tumour dominance. This study proposes immunomodulatory mechanisms based on metabolic reprogramming and employs the regulatory flux balance analysis modelling approach, which integrates signalling, metabolism and regulatory processes. For the first time, a comprehensive system-level model is constructed to capture signalling and metabolic cross-talks during tumour-immune interaction and regulatory constraints are incorporated by considering the time lag bet

SUBMITTER: Shukla M 

PROVIDER: S-EPMC10933535 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature