X-Ray Visible Protein Scaffolds by Bulk Iodination.

ABSTRACT: Protein-based biomaterial use is expanding within medicine, together with the demand to visualize their placement and behavior in vivo. However, current medical imaging techniques struggle to differentiate between protein-based implants and surrounding tissue. Here a fast, simple, and translational solution for tracking transplanted protein-based scaffolds is presented using X-ray CT-facilitating long-term, non-invasive, and high-resolution imaging. X-ray visible scaffolds are engineered by selectively iodinating tyrosine residues under mild conditions using readily available reagents. To illustrate translatability, a clinically approved hernia repair mesh (based on decellularized porcine dermis) is labeled, preserving morphological and mechanical properties. In a mouse model of mesh impla

SUBMITTER: Flechas Becerra C 

PROVIDER: S-EPMC10933627 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature