Two-Phase Fermentation Systems for Microbial Production of Plant-Derived Terpenes.

ABSTRACT: Microbial cell factories, renowned for their economic and environmental benefits, have emerged as a key trend in academic and industrial areas, particularly in the fermentation of natural compounds. Among these, plant-derived terpenes stand out as a significant class of bioactive natural products. The large-scale production of such terpenes, exemplified by artemisinic acid-a crucial precursor to artemisinin-is now feasible through microbial cell factories. In the fermentation of terpenes, two-phase fermentation technology has been widely applied due to its unique advantages. It facilitates in situ product extraction or adsorption, effectively mitigating the detrimental impact of product accumulation on microbial cells, thereby significantly bolstering the efficiency of microbial production

SUBMITTER: Li T 

PROVIDER: S-EPMC10934027 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature