Multivariate Analysis of Cellular Uptake Characteristics for a (Co)polymer Particle Library.

ABSTRACT: Controlling cellular responses to nanoparticles so far is predominantly empirical, typically requiring multiple rounds of optimization of particulate carriers. In this study, a systematic model-assisted approach should lead to the identification of key parameters that account for particle properties and their cellular recognition. A copolymer particle library was synthesized by a combinatorial approach in soap free emulsion copolymerization of styrene and methyl methacrylate, leading to a broad compositional as well as constitutional spectrum. The proposed structure-property relationships could be elucidated by multivariate analysis of the obtained experimental data, including physicochemical characteristics such as molar composition, molecular weight, particle diameter, and particle charg

SUBMITTER: Baudis S 

PROVIDER: S-EPMC10934412 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature