The Effect of Stereocomplexation and Crystallinity on the Degradation of Polylactide Nanoparticles.

ABSTRACT: Polymeric nanoparticles (PNPs) are frequently researched and used in drug delivery. The degradation of PNPs is highly dependent on various properties, such as polymer chemical structure, size, crystallinity, and melting temperature. Hence, a precise understanding of PNP degradation behavior is essential for optimizing the system. This study focused on enzymatic hydrolysis as a degradation mechanism by investigation of the degradation of PNP with various crystallinities. The aliphatic polyester polylactide ([C₃H₄O₂]n, PLA) was used as two chiral forms, poly l-lactide (PlLA) and poly d-lactide (PdLA), and formed a unique crystalline stereocomplex (SC). PNPs were prepared via a nanoprecipitation method. In order to further control the crystallinity and melting

SUBMITTER: Yin C 

PROVIDER: S-EPMC10934930 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature