MicroRNA Expression Profile in Obesity-Induced Kidney Disease Driven by High-Fat Diet in Mice.

ABSTRACT: Obesity is one of the main causes of chronic kidney disease; however, the precise molecular mechanisms leading to the onset of kidney injury and dysfunction in obesity-associated nephropathy remain unclear. The present study aimed to unveil the kidney microRNA (miRNA) expression profile in a model of obesity-induced kidney disease in C57BL/6J mice using next-generation sequencing (NGS) analysis. High-fat diet (HFD)-induced obesity led to notable structural alterations in tubular and glomerular regions of the kidney, increased renal expression of proinflammatory and profibrotic genes, as well as an elevated renal expression of genes involved in cellular lipid metabolism. The miRNA sequencing analysis identified a set of nine miRNAs differentially expressed in the kidney upon HFD feeding, wi

SUBMITTER: Eritja A 

PROVIDER: S-EPMC10934936 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature