Epigenetic modification in liver fibrosis: Promising therapeutic direction with significant challenges ahead.

ABSTRACT: Liver fibrosis, characterized by scar tissue formation, can ultimately result in liver failure. It's a major cause of morbidity and mortality globally, often associated with chronic liver diseases like hepatitis or alcoholic and non-alcoholic fatty liver diseases. However, current treatment options are limited, highlighting the urgent need for the development of new therapies. As a reversible regulatory mechanism, epigenetic modification is implicated in many biological processes, including liver fibrosis. Exploring the epigenetic mechanisms involved in liver fibrosis could provide valuable insights into developing new treatments for chronic liver diseases, although the current evidence is still controversial. This review provides a comprehensive summary of the regulatory mechanisms and cr

SUBMITTER: Liu R 

PROVIDER: S-EPMC10935124 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature