Mapping the widespread distribution and transmission dynamics of linezolid resistance in humans, animals, and the environment.

ABSTRACT:

Background

The rise of linezolid resistance has been widely observed both in clinical and non-clinical settings. However, there were still data gaps regarding the comprehensive prevalence and interconnections of linezolid resistance genes across various niches.

Results

We screened for potential linezolid resistance gene reservoirs in the intestines of both humans and animals, in meat samples, as well as in water sources. A total of 796 bacteria strains out of 1538 non-duplicated samples were identified to be positive for at least one linezolid resistance gene, optrA, poxtA, cfr, and cfr(D). The prevalence of optrA reached 100% (95% CI 96.3-100%) in the intestines of pigs, followed by fish, ducks, and chicken at 77.5% (95% CI 67.2-85.3%), 62.0% (95% CI 52.2-70.9%), and 61.0%

SUBMITTER: Shen W 

PROVIDER: S-EPMC10936028 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature