Survival time prediction in patients with high-grade serous ovarian cancer based on ¹⁸F-FDG PET/CT- derived inter-tumor heterogeneity metrics.

ABSTRACT:

Background

The presence of heterogeneity is a significant attribute within the context of ovarian cancer. This study aimed to assess the predictive accuracy of models utilizing quantitative ¹⁸F-FDG PET/CT derived inter-tumor heterogeneity metrics in determining progression-free survival (PFS) and overall survival (OS) in patients diagnosed with high-grade serous ovarian cancer (HGSOC). Additionally, the study investigated the potential correlation between model risk scores and the expression levels of p53 and Ki-67.

Methods

A total of 292 patients diagnosed with HGSOC were retrospectively enrolled at Shengjing Hospital of China Medical University (median age: 54 ± 9.4 years). Quantitative inter-tumor heterogeneity metrics were calculated based on conventional meas

SUBMITTER: He D 

PROVIDER: S-EPMC10936071 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature